FIG. 1 (above) illustrates a proposed biodegradable grid scaffold item 5 and biodegradable hair follicles containing sheet item 14 in accordance with an exemplary embodiment of the present disclosure.

We’ve patent filed the following PCT:

Abstract & technical field

The present disclosure relates to a bioengineering process to derive hair follicles in vitro from the in vitro disposition and differentiation of pluripotent stem cells and dermal papilla cells. The present disclosure also relates to bioengineering of hair follicles and hair follicle containing sheets with asymmetric disposition of hair shafts. The present disclosure also relates to a bioengineering process to derive hair follicle containing sheets in vitro from a biodegradable supportive grid and said in vitro derived hair follicles. The present disclosure also relates to the controlled asymmetry of the hair shaft on said hair follicle containing sheets. The present disclosure also relates to the field of cosmetic materials and method for reconstructing hair follicle containing materials in vitro.

Brief Description of Drawings:

The accompanying drawings are included to provide a further understanding of the present disclosure and are incorporated in and constitute a part of this specification. The drawings illustrate exemplary embodiments of the present disclosure and, together with the description, serve to explain the principles of the present disclosure.
In the figures, similar components and/or features may have the same reference label. Further, various components of the same type may be distinguished by following the reference label with a second label that distinguishes among the similar components. If only the first reference label is used in the specification, the description is applicable to any one of the similar components having the same first reference label irrespective of the second reference label.

FIG. 2 (down) illustrates a proposed three-dimensional cell aggregate item 7 and bioengineered hair follicle item 12 in accordance with an exemplary embodiment of the present disclosure.